منابع مشابه
Characterization of Rotavirus RNAs That Activate Innate Immune Signaling through the RIG-I-Like Receptors
In mammalian cells, the first line of defense against viral pathogens is the innate immune response, which is characterized by induction of type I interferons (IFN) and other pro-inflammatory cytokines that establish an antiviral milieu both in infected cells and in neighboring uninfected cells. Rotavirus, a double-stranded RNA virus of the Reoviridae family, is the primary etiological agent of...
متن کاملHow RIG-I like receptors activate MAVS.
RIG-I and MDA5 are well-conserved cytoplasmic pattern recognition receptors that detect viral RNAs during infection and activate the type I interferon (IFN)-mediated antiviral immune response. While much is known about how these receptors recognize viral RNAs, how they interact with their common signaling adaptor molecule MAVS and activate the downstream signaling pathway had been less clear. P...
متن کاملSensing viral invasion by RIG-I like receptors.
Cellular responses to pathogen invasion are crucial for maintaining cell homeostasis and survival. The interferon (IFN) system is one of the most effective cellular responses to viral intrusion in mammals. Viral recognition by innate immune sensors activates the antiviral IFN system. Retinoic acid-inducible gene I (RIG-I) like receptors (RLRs) are DExD/H box RNA helicases that sense viral invas...
متن کاملIntracellular pathogen detection by RIG-I-like receptors.
The RIG-I-like receptors (RLRs) RIG-I, MDA5, and LGP2 trigger innate immune responses against viral infections that serve to limit virus replication and to stimulate adaptive immunity. RLRs are cytosolic sensors for virus-derived RNA and thus responsible for intracellular immune surveillance against infection. RLR signaling requires the adapter protein MAVS to induce type I interferon, interfer...
متن کاملToll-like receptors, RIG-I-like RNA helicases and the antiviral innate immune response.
The antiviral innate immune response follows the detection of viral components by host pattern recognition receptors (PRRs). Two families of PRRs have emerged as key sensors of viral infection: Toll-like receptors (TLRs) and retinoic acid inducible gene-I like RNA helicases (RLHs). TLRs patrol the extracellular and endosomal compartments; signalling results in a type-1 interferon response and/o...
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ژورنال
عنوان ژورنال: Immunity
سال: 2011
ISSN: 1074-7613
DOI: 10.1016/j.immuni.2011.05.003